1-Naphthohydroxamic acid

SKU: orb1308735

Description

1-Naphthohydroxamic acid is a selective HDAC8 inhibitor (IC50 = 14 μM) with minimal activity against HDAC1 and HDAC6 (IC50 >100 μM). It induces tubulin acetylation without affecting global histone H4 acetylation or total intracellular HDAC activity, making it a useful tool for studying HDAC8-specific roles in cellular processes.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 6953-61-3
• MW: 187.19
• Purity: 99.19% (May vary between batches)
• Formula: C₁₁H₉NO₂
• SMILES: ONC(=O)c1cccc2ccccc12
• Target: HDAC
• Solubility: DMSO:125 mg/mL (667.77 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

deacetylate, hyperacetylated, Histone deacetylases, HDAC6, HDAC, HDAC1, HDAC8, Inhibitor, inhibit, clone, 1Naphthohydroxamic acid, 1-Naphthohydroxamic acid, 1 Naphthohydroxamic acid, acetylation, anti-proliferation, tubulin

Quick Database Links

Gene Symbol

HDAC