A-366

SKU: orb1226148

Description

A-366 is a potent, highly selective inhibitor of histone methyltransferase G9a/GLP with IC50 of 3/38 nM, >1,000-fold selectivity for G9a over 21 other methyltransferases; effects a clear reduction in H3K9 methylation in cells, shows significantly less cytotoxic effects on the growth of tumor cell lines compared to other known G9a/GLP small molecule inhibitors despite equivalent cellular activity on methylation of H3K9me2 (H3K9me2 cellular EC50=0.3 uM); induces differentiation and affects viability in MV4;11 cells, demonstrates growth inhibition in vivo consistent with the profile of H3K9me2 reduction in flank xenograft leukemia model.

Key Properties

• CAS Number: 1527503-11-2
• MW: 329.4366
• Purity: >98% (HPLC)
• Formula: C₁₉H₂₇N₃O₂
• SMILES: NC(C12CCC1)=NC3=C2C=C(OC)C(OCCCN4CCCC4)=C3
• Target: HMTase
• Solubility: 10 mM in DMSO

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

A366

Quick Database Links

Gene Symbol

HMTase