AC-264613

SKU: orb1223443

Description

AC-264613 is the first agonist of the G-protein-coupled receptor (GPCR) protease activated receptor 2 (PAR2). AC-264613 suppresses interferon regulatory factor 5 and decreases interleukin-12p40 production by lipopolysaccharide-stimulated macrophages. AC-264613 activated PAR2 signaling in cellular proliferation assays, phosphatidylinositol hydrolysis assays, and Ca(2+) mobilization assays, with potencies ranging from 30 to 100 nM.

Key Properties

• CAS Number: 1051487-82-1
• MW: 400.28
• Purity: >98% (HPLC)
• Formula: C₁₉H₁₈BrN₃O₂
• SMILES: O=C([C@H]1C(=O)NC[C@@H]1c1ccccc1)N/N=C(/c1cccc(Br)c1)\C
• Target: PAR-2

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AC-264613 | AC 264613 | AC264613

Quick Database Links

Gene Symbol

PAR-2