ADH-503

SKU: orb1299517

Description

ADH-503 (GB1275) is an orally active, allosteric agonist of CD11b. It reprograms tumor-associated macrophages, reduces immunosuppressive myeloid cell infiltration, and enhances dendritic cell activity. This small molecule is utilized in immuno-oncology research to study macrophage polarization and antitumor immune responses in both cellular and animal models.

Research Area

Immunology & Inflammation, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 2055362-74-6
• MW: 524.7
• Purity: 97.03% (May vary between batches)
• Formula: C₂₇H₂₈N₂O₅S₂
• SMILES: C[N+](C)(C)CCO.[O-]C(=O)c1ccc(cc1)-c1ccc(\C=C2/SC(=S)N(Cc3ccccc3)C2=O)o1
• Target: Complement System,Integrin
• Solubility: DMSO:5.25 mg/mL (10.01 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Complement System, ComplementSystem, CD11b, dendritic, ADH503, ADH-503, ADH 503, allosteric, Inhibitor, GB1275, GB-1275, GB 1275, macrophages, orally, inhibit, immunosuppressive, repolarization, tumorassociated, tumor-infiltrating

Quick Database Links

Gene Symbol

Complement System,Integrin