Amantadine hydrochloride

SKU: orb1224297

Description

Amantadine Hydrochloride is an antiviral and an antiparkinsonian drug.(In Vitro):Amantadine hydrochloride (0-500 μM, 26 h) inhibits SARS-CoV-2 replication, with IC50 concentrations between 83 and 119 μM.Amantadine hydrochloride (0-100 μg/mL, 24-72 h) markedly inhibits the proliferation of HepG2 and SMMC 7721 cells.Amantadine hydrochloride (0-75 μg/mL, 48 h) arrests the cell cycle at the G0/G1 phase and induces apoptosis.Amantadine hydrochloride (0-75 μg/mL, 48 h) reduces the levels of the cell cycle related genes and proteins (cyclin D1, cyclin E and CDK2), reduces Bcl-2 and increases the Bax protein and mRNA levels.(In Vivo):Amantadine hydrochloride (25 mg/kg, IP, once daily for 3 days) inhibits surgery induced neuroinflammation and learning and memory impairment.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 665-66-7
• MW: 187.71
• Purity: >98% (HPLC)
• Formula: C₁₀H₁₈ClN
• SMILES: Cl.NC12CC3CC(CC(C3)C1)C2
• Target: Dopamine Receptor
• Solubility: Ethanol: 38 mg/mL (202.45 mM); Water: 38 mg/mL (202.45 mM); DMSO: 38 mg/mL (202.45 mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Adamantylamine | Aminoadamantane | NSC 83653

Quick Database Links

Gene Symbol

Dopamine Receptor