AMG 487

SKU: orb1310006

Description

AMG 487 is a selective small molecule CXCR3 antagonist, potently blocking CXCL10 and CXCL11 binding with IC50 values of approximately 8 nM. It is widely used in research to investigate the role of CXCR3 in autoimmune diseases, transplant rejection, and cancer biology, employing both in vitro binding assays and in vivo disease models.

Research Area

Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 473719-41-4
• MW: 603.59
• Purity: 99.82% (May vary between batches)
• Formula: C₃₂H₂₈F₃N₅O₄
• SMILES: CCOc1ccc(cc1)-n1c(nc2ncccc2c1=O)[C@@H](C)N(Cc1cccnc1)C(=O)Cc1ccc(OC(F)(F)F)cc1
• Target: CXCR
• Solubility: DMSO:41 mg/mL (67.93 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.31 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

receptor, cancer, 125I-IP10-CXCR3, 125I-ITAC-CXCR3, AMG 487, AMG487, AMG-487, colon, Breast, chemokine, CXCR3, CXCR, CXC chemokine receptors, CXCL11, CXCL10, Metastatic, metastasis, inhibit, Inhibitor

Quick Database Links

Gene Symbol

CXCR