AMG 837 calcium hydrate

SKU: orb1296266

Description

AMG 837 calcium hydrate is a potent and selective GPR40 agonist (EC50 = 13 nM), exhibiting over 1000-fold selectivity against related receptors GPR41, GPR43, and GPR120. This small molecule is a valuable research tool for investigating GPR40's role in glucose homeostasis and insulin secretion in both cellular and animal models of diabetes.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1259389-38-2
• MW: 950.97
• Purity: 98.07% (May vary between batches)
• Formula: C₅₂H₄₄CaF₆O₈
• SMILES: [H]O[H].[H]O[H].O=C([O-])C[C@H](C#CC)C1=CC=C(OCC2=CC(C3=CC=C(C(F)(F)F)C=C3)=CC=C2)C=C1.O=C([O-])C[C@H](C#CC)C4=CC=C(OCC5=CC(C6=CC=C(C(F)(F)F)C=C6)=CC=C5)C=C4.[Ca+2]
• Target: GPCR
• Solubility: DMSO:40 mg/mL (42.06 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AMG 837 calcium, AMG 837 calcium Hydrate, AMG 837 calcium hydrate, Inhibitor, insulin, GPR40, glucose, FFAR, FFA1, Free Fatty Acid Receptor, inhibit

Quick Database Links

Gene Symbol

GPCR