Amlodipine

SKU: orb1223755

Description

Amlodipine is a long-acting calcium channel blocker. Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the movement of calcium ions into vascular smooth muscle cells and cardiac muscle cells.(In Vitro):Amlodipine (20-40 μM; 48 h) reduces BrdU incorporation to 68.6% and 26.3% at concentrations of 20 and 30 μM in A431 cells, respectively.Amlodipine (30 μM; pretreated for 1 h) significantly attenuates the uridine 5′-triphosphate (UTP)-induced increases of [Ca2+]i in A431 cells.Amlodipine (30 μM) inhibits the store-operated Ca2+influx evoked by Thapsigargin in Fluo-3-loaded cells.(In Vivo):Amlodipine (5 mg/kg/day; s.c. for 2 weeks) significantly decreases systolic blood pressure (SBP) in VSMC ATP2B1 KO mice.Amlodipine (10 mg/kg; i.p. once daily for 20 days) causes a significant retardation of tumor growth and prolongs the survival of A431 tumor-bearing mice.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 88150-42-9
• MW: 408.88
• Purity: >98% (HPLC)
• Formula: C₂₀H₂₅ClN₂O₅
• SMILES: OS(=O)(=O)C1=CC=CC=C1.CCOC(=O)C1=C(COCCN)NC(C)=C(C1C1=CC=CC=C1Cl)C(=O)OC
• Target: Calcium Channel
• Solubility: Ethanol: 82 mg/mL (200.54 mM); DMSO: 82 mg/mL (200.54 mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Intervask | Pelmec

Quick Database Links

Gene Symbol

Calcium Channel