Amsilarotene

SKU: orb1306403

Description

Amsilarotene (TAC101) induces cell cycle arrest by inhibiting retinoblastoma (RB) protein phosphorylation and upregulating CDK inhibitors. It also exerts cytotoxic effects through downregulation of thymidylate synthase and cyclin A. This mechanism supports its research application in studying cancer cell proliferation in both in vitro and in vivo models.

Research Area

Cell Biology, Metabolism Research

Key Properties

• CAS Number: 125973-56-0
• MW: 385.6
• Purity: 98.05% (May vary between batches)
• Formula: C₂₀H₂₇NO₃Si₂
• SMILES: C[Si](C)(C)c1cc(cc(c1)[Si](C)(C)C)C(=O)Nc1ccc(cc1)C(O)=O
• Target: Retinoid Receptor,CDK,Apoptosis
• Solubility: DMSO:60 mg/mL (155.6 mM);H2O:Insoluble;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.19 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Am 555S, BxPC-3, cancer, AsPC-1, Amsilarotene, Apoptosis, CDK, inhibit, MIAPaCa-2, Inhibitor, Retinoic acid receptors, Retinoid X receptors, RMG-II, TAC 101, TAC101, TAC-101, RAR/RXR, orally active

Quick Database Links

Gene Symbol

Retinoid Receptor,CDK,Apoptosis