Amuvatinib

SKU: orb1305369

Description

Amuvatinib (MP470) is an orally available small molecule investigational agent with potential antitumor properties. It has been studied in vitro and in vivo for its activity against various cancer cell lines, particularly in research focusing on receptor tyrosine kinase inhibition and DNA repair pathways.

Research Area

Cardiovascular Research, Cell Biology, Molecular Biology, Signal Transduction

Key Properties

• CAS Number: 850879-09-3
• MW: 447.51
• Purity: 98.48% (May vary between batches)
• Formula: C₂₃H₂₁N₅O₃S
• SMILES: C(NCC=1C=C2C(=CC1)OCO2)(=S)N3CCN(C4=C5C(C=6C(O5)=CC=CC6)=NC=N4)CC3
• Target: c-RET,c-Met/HGFR,FLT,c-Kit,PDGFR,Apoptosis,DNA/RNA Synthesis
• Solubility: DMSO:50 mg/mL (111.73 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.47 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DNA Synthesis, DNASynthesis, cRET, CD117, Cluster of differentiation antigen 135, CD135, c-Kit, cKit, c-Kit (D816H), cMet, cMet/HGFR, c-Met, c-Met/HGFR, Apoptosis, Amuvatinib, inhibit, MP 470, MP470, MP-470, Platelet-derived growth factor receptor, PDGFR, Fms like tyrosine kinase 3, FLT3, FLT3 (D835Y), Inhibitor, HGFR, HPK56, HPK-56, HPK 56, RAD51, PDGFRα (V561D), RNA Synthesis, RNASynthesis, RET, SCFR

Quick Database Links

Gene Symbol

c-RET,c-Met/HGFR,FLT,c-Kit,PDGFR,Apoptosis,DNA/RNA Synthesis