Ancitabine hydrochloride

SKU: orb1308083

Description

Ancitabine hydrochloride is a prodrug of cytarabine that undergoes slow hydrolysis to release the active antimetabolite. Its conversion provides sustained cytarabine levels, leading to S-phase-specific termination of DNA replication and inhibition of DNA polymerase, which is utilized in oncology research for studying leukemia and solid tumor models both in vitro and in vivo.

Research Area

Cell Biology, Infectious Disease & Virology, Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 10212-25-6
• MW: 261.66
• Purity: 99.02% (May vary between batches)
• Formula: C₉H₁₂ClN₃O₄
• SMILES: Cl.[C@@H]12[C@@H](Oc3n1ccc(=N)n3)[C@@H]([C@H](O2)CO)O
• Target: Virus Protease,Autophagy,DNA/RNA Synthesis
• Solubility: H2O:26.31 mg/mL (100.55 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.82 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:10 mg/mL (38.22 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NSC 145668 HCl, Ancitabine, Autophagy, CMV, DNA Synthesis, DNA/RNA Synthesis, DNASynthesis, Cyclo-C, Cyclo-C HCl, Cyclo-CMP, Cyclo-CMP hydrochloride, Cyclocytidine, Cyclocytidine HCl, Cyclocytidine hydrochloride, RNASynthesis, RNA Synthesis

Quick Database Links

Gene Symbol

Virus Protease,Autophagy,DNA/RNA Synthesis