Apigenin-7-glucuronide

SKU: orb1220896

Description

Apigenin-7-glucuronide possesses multiple activities including antioxidant anti-inflammatory and aldose reductase inhibitory activities it can inhibit MMP activities (IC50s: 12.87 22.39 17.52 0.27 μM for MMP-3 MMP-8 MMP-9 MMP-13 respectively).(In Vitro):Apigenin-7-Oglucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively . Scutellarin A also inhibits the migrated capacity of ACHN and 786-O cells in a dose-dependent manner. It is also revealed that after treatment with Scutellarin A (30, 60, and 90 μM) for 24 h, the apoptosis rates in ACHN and 786-O cells are remarkably enhanced dose-dependently when compared to the control groups.

Key Properties

• CAS Number: 29741-09-1
• MW: 446.36
• Purity: >98% (HPLC)
• Formula: C₂₁H₁₈O₁₁
• SMILES: O[C@H]1[C@H](Oc2cc(O)c3c(c2)oc(cc3=O)-c2ccc(O)cc2)O[C@@H]([C@@H](O)[C@@H]1O)C(O)=O
• Target: MMP
• Solubility: DMSO: 50 mg/mL (112.02 mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apigenin 7-O-glucuronide

Quick Database Links

Gene Symbol

MMP