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Asciminib

SKU: orb1302024

Description

Asciminib (ABL001) is a highly potent and selective allosteric Bcr-Abl inhibitor with sub-nanomolar binding affinity. It is widely used in research for chronic myeloid leukemia (CML), demonstrating efficacy in both cellular assays and in vivo models to study resistance mechanisms and therapeutic strategies.

Research Area

Cardiovascular Research, Signal Transduction

Images & Validation

Key Properties

CAS Number1492952-76-7
MW449.84
Purity97.93% (May vary between batches)
FormulaC20H18ClF2N5O3
SMILESC(NC1=CC=C(OC(Cl)(F)F)C=C1)(=O)C2=CC(=C(N=C2)N3CC[C@@H](O)C3)C=4C=CNN4
TargetBcr-Abl
SolubilityH2O:Insoluble;DMSO:245 mg/mL (544.64 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.45 mM)

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Bcr-Abl, BcrAbl, Asciminib, ABL 001, ABL001, ABL-001, Abl1, inhibit, Inhibitor

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  • Asciminib [orb1226189]

    >98% (HPLC)

    1492952-76-7

    449.843

    C20H18ClF2N5O3

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Asciminib (orb1302024)

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Available Sizes

Select a size below

1 mg
$ 100.00
2 mg
$ 130.00
5 mg
$ 170.00
1 ml x 10 mM (in DMSO)
$ 190.00
10 mg
$ 240.00
25 mg
$ 370.00
50 mg
$ 490.00
100 mg
$ 710.00
500 mg
$ 1,430.00
DispatchUsually dispatched within 3-5 working days
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