AZ7550 hydrochloride

SKU: orb1308863

Description

AZ7550 hydrochloride is the active metabolite of AZD9291 (Osimertinib) and acts as an IGF1R inhibitor with an IC50 of 1.6 µM. This small molecule is a valuable research tool for studying IGF-1R signaling in cancer models, applicable in both in vitro biochemical assays and in vivo preclinical research.

Research Area

Cardiovascular Research, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 2309762-40-9
• MW: 522.04
• Purity: 97.07% (May vary between batches)
• Formula: C₂₇H₃₂ClN₇O₂
• SMILES: C=CC(NC1=CC(NC2=NC=CC(C3=CN(C4=C3C=CC=C4)C)=N2)=C(C=C1N(CCNC)C)OC)=O.[H]Cl
• Target: IGF-1R,Drug Metabolite,EGFR
• Solubility: DMSO:1.5 mg/mL (2.87 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PYK2, Txk, TEC, Ins R, Inhibitor, HER1, FLT4, IGF-1R, IGF1R, FLT3, FES, FAK, ErbB4, ErbB-1, EGFR, Epidermal growth factor receptor, IRR, inhibit, MNK2, MLK1, AZ7550, AZ-7550, AZ7550 hydrochloride, AZ7550 Hydrochloride, AZ-7550 Hydrochloride, AZ-7550 hydrochloride, AZ7550 hydrochloride (1421373-99-0 free base), AZ 7550, AZ 7550 Hydrochloride, BLK, BTK, 1421373-99-0, 1421373-99-0 free base, ACK1, ALK, BRK, Drug Metabolite

Quick Database Links

Gene Symbol

IGF-1R,Drug Metabolite,EGFR