AZD8330

SKU: orb1301088

Description

AZD8330 (ARRY-704) is a potent and selective allosteric inhibitor of MEK1/2, demonstrating an IC50 of 7 nM. This investigational compound has been utilized in preclinical in vitro and in vivo studies to explore its potential in oncology research, particularly targeting the MAPK signaling pathway.

Research Area

Signal Transduction

Key Properties

• CAS Number: 869357-68-6
• MW: 461.23
• Purity: 98.72% (May vary between batches)
• Formula: C₁₆H₁₇FIN₃O₄
• SMILES: Cc1cc(C(=O)NOCCO)c(Nc2ccc(I)cc2F)n(C)c1=O
• Target: MEK,ERK
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:85 mg/mL (184.29 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2.5 mg/mL (5.42 mM);Ethanol:85 mg/mL (184.29 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MEK, MEK1/2, MAPKK, MAP2K, Inhibitor, ERK phosphorylation, Mitogen-activated protein kinase kinase, inhibit, AZD8330, AZD-8330, ARRY704, ARRY-704, ARRY424704, ARRY-424704, ARRY 704, ARRY 424704, AZD 8330

Quick Database Links

Gene Symbol

MEK,ERK