Azelastine hydrochloride

SKU: orb1223994

Description

Azelastine HCl is a potent, second-generation, selective, histamine antagonist.(In Vitro):Azelastine hydrochloride can significantly inhibit HNEpC proliferation, and therefore, be helpful in against airway remodeling.(In Vivo):Azelastine hydrochloride (4 mg/kg; p.o.; daily; for 8 weeks) significantly reduces blood glucose, HbA1c and serum alkaline phosphatase (ALP), osteocalcin and downregulates apolipoprotein B in diabetic hyperlipidemic rats model.Azelastine hydrochloride (4 mg/kg; p.o.; daily; for 8 weeks) improves the lipid profile (LDL-c decrease and HDL-c increase) in diabetic hyperlipidemic rats model.Azelastine hydrochloride (4 mg/kg; p.o.; daily; for 8 weeks) attenuates calcium deposition and aortic calcification in diabetic hyperlipidemic rats model.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 79307-93-0
• MW: 418.36
• Purity: >98% (HPLC)
• Formula: C₂₂H₂₄ClN₃O·HCl
• SMILES: CN1CCCC(CC1)N2C(=O)C3=CC=CC=C3C(=N2)CC4=CC=C(C=C4)Cl.Cl
• Target: Histamine Receptor
• Solubility: Ethanol: 84 mg/mL (200.78 mM); Water: 35 mg/mL (83.66 mM); DMSO: 84 mg/mL (200.78 mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Azelastine HCl | Astelin | Optivar | Allergodil | Rhinolast | Azeptin

Quick Database Links

Gene Symbol

Histamine Receptor