Baclofen

SKU: orb1226943

Description

A derivative of the neurotransmitter GABA that acts as a GABAB receptor agonist; also blocks α2δ subunit-containing voltage-dependent calcium channel (VDCC) with Ki of 156 uM; A neurotransmitter inhibitor by blocking the release of excitatory transmitters; serves as a central nervous system depressant and skeletal muscle relaxant.Other Indication Approved(In Vitro):Baclofen (1, 10 μM; 24 h) causes markedly decreased lactate dehydrogenase (LDH) activity, indicating increased cell viability in wild-type or mutant huntingtin-expressing striatal cells (HD19 or HD43). Baclofen significantly increases chymotrypsin-like proteasome activity and cell viability were in the HD43 cells.(In Vivo):Baclofen (i.p.; 10 μg/g; twice daily for 3 consecutive days) ameliorates motor deficits in YAC128 HD transgenic mice.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1134-47-0
• MW: 213.6608
• Purity: >98% (HPLC)
• Formula: C₁₀H₁₂ClNO₂
• SMILES: O=C(O)CC(C1=CC=C(Cl)C=C1)CN
• Target: GAT
• Solubility: DMSO: < 7.8 mg/mL

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Baclofen | Lioresal, Liofen, Gablofen | Baclon | Kemstro

Quick Database Links

Gene Symbol

GAT