Bafilomycin A1

SKU: orb1300510

Description

Bafilomycin A1 is a specific and reversible macrolide antibiotic that potently inhibits V-ATPase (IC50=0.44 nM). It blocks autophagosome-lysosome fusion, arresting late-stage autophagy, and can induce apoptosis, making it a valuable tool for studying autophagy, cancer, and neurodegeneration in cellular and animal models.

Research Area

Cell Biology

Key Properties

• CAS Number: 88899-55-2
• MW: 622.8
• Purity: >98%
• Formula: C₃₅H₅₈O₉
• SMILES: [H][C@@]1(OC(=O)\C(OC)=C\C(\C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C\C(C)=C\C=C\[C@@H]1OC)[C@@H](C)[C@@H](O)[C@H](C)[C@@]1(O)C[C@@H](O)[C@H](C)[C@H](O1)C(C)C
• Target: ATPase
• Solubility: Soluble in DMSO (up to 50 mg/ml)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

From Streptomyces griseus

Quick Database Links

Gene Symbol

ATPase