BAR 501

SKU: orb1223256

Description

BAR-501 is a selective GPBAR1 agonist devoid of any FXR agonistic activity. BAR501 effectively reduced hepatic perfusion pressure and counteracted the vasoconstriction activity of norepinephrine. BAR501 rescues from endothelial dysfunction in rodent models of portal hypertension by exerting genomic and non-genomic effects on CSE, eNOS and ET-1 in liver sinusoidal cells.

Key Properties

• CAS Number: 1632118-69-4
• MW: 406.65
• Purity: >98% (HPLC)
• Formula: C₂₆H₄₆O₃
• SMILES: CC[C@H]1[C@@H]2C[C@@H](CC[C@@]2([C@H]2CC[C@]3([C@H]([C@@H]2[C@H]1O)CC[C@@H]3[C@H](C)CCCO)C)C)O
• Target: Monocarboxylate Transporter
• Solubility: DMSO : ≥ 50 mg/mL. 122.96 mM

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BAR-501 | BAR 501 | BAR501

Quick Database Links

Gene Symbol

Monocarboxylate Transporter