BAR502

SKU: orb1296098

Description

BAR502 is a dual agonist targeting both the GPBAR1 (TGR5) and FXR receptors, with respective IC50 values of 0.4 μM and 2 μM. This small molecule is a valuable research tool for investigating metabolic and inflammatory pathways in both in vitro and in vivo models of liver and intestinal diseases.

Research Area

Cell Biology, Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1612191-86-2
• MW: 392.62
• Purity: 99.91% (May vary between batches)
• Formula: C₂₅H₄₄O₃
• SMILES: CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@H]([C@H](C)CCO)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12
• Target: Autophagy,FXR,GPCR19
• Solubility: DMF:48 mg/mL (122.26 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BAR 502, BAR502, BAR-502, Autophagy, G-protein coupled receptor 19, GPBAR1, GPCR19, FXR, G protein-coupled Bile Acid Receptor 1, Inhibitor, NR1H4, inhibit, TGR5

Quick Database Links

Gene Symbol

Autophagy,FXR,GPCR19