BAY 11-7082

SKU: orb1307179

Description

BAY 11-7082 (also known as BAY 11-7821) is a cell-permeable small molecule that potently inhibits the deubiquitinases USP7 and USP21, and also suppresses NF-κB activation by blocking TNFα-induced IκBα phosphorylation. This dual activity makes it a valuable research tool for studying inflammatory signaling, immune regulation, and cancer pathways in both cellular and animal models.

Research Area

Cell Biology, Neuroscience

Key Properties

• CAS Number: 19542-67-7
• MW: 207.3
• Purity: >98%
• Formula: C₁₀H₉NO₂S
• SMILES: Cc1ccc(cc1)S(=O)(=O)\C=C\C#N
• Target: Kinase
• Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 15 mg/ml).

Storage & Handling

• Storage: RT
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ubiquitin, T-cell, phosphorylation, adhesion, Apoptosis, Autophagy, BAY 117082, BAY 11-7082, BAY 11-7821, BAY 11 7082, B-cell, cytokine, Deubiquitinase, DUBs, I kappa B kinase, leukaemic, IKK, IkB, IkB/IKK, E2-conjugating enzymes, Inhibitor, inhibit, IκBα phosphorylation, IκB, IκB kinase, inflammasome, lymphoma

Quick Database Links

Gene Symbol

Kinase

J Guo, X Ma, L Wu, W Zhao, Y Zhang, C Hao, Y Yang, Z Yin, T Xu, Y Zhang, Y Guo, X Cao Inhibition of Nuclear factor kappa B ameliorates bone destruction and osteoclastogenesis in collagen-induced arthritis mice African Health Sciences, (2025)

PubMed: 41640567