BI-847325

SKU: orb1300468

Description

BI-847325 is a potent small molecule that selectively inhibits both MEK2 and Aurora Kinase C with IC50 values of 4 nM and 15 nM, respectively. It is utilized in cancer research to study pathway signaling and has demonstrated antitumor activity in both cellular assays and in vivo xenograft models.

Research Area

Cell Biology, Epigenetics & Chromatin, Signal Transduction

Key Properties

• CAS Number: 1207293-36-4
• MW: 464.56
• Purity: 95.22% (May vary between batches)
• Formula: C₂₉H₂₈N₄O₂
• SMILES: CCNC(=O)C#Cc1ccc2\C(=C(\Nc3ccc(CN(C)C)cc3)c3ccccc3)C(=O)Nc2c1
• Target: Apoptosis,MEK,Aurora Kinase
• Solubility: Ethanol:1 mg/mL (2.15 mM);DMSO:18 mg/mL (38.75 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.15 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apoptosis, AuroraKinase, Aurora Kinase, Aurora B (Xenopus laevis), Aurora C (Human), Aurora A (Human), BI847325, BI-847325, BI 847325, MAPKK, MAP2K, MEK, MEK1, MEK2, Inhibitor, Mitogen-activated protein kinase kinase, inhibit

Quick Database Links

Gene Symbol

Apoptosis,MEK,Aurora Kinase