Bicuculline

SKU: orb1304933

Description

Bicuculline is a natural alkaloid that acts as a competitive GABAA receptor antagonist (IC50 = 2 µM) and a blocker of SK potassium channels. It is widely utilized in neuroscience research to induce seizures in animal models and to study synaptic inhibition and neuronal excitability in vitro.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 485-49-4
• MW: 367.35
• Purity: 98.00% (May vary between batches)
• Formula: C₂₀H₁₇NO₆
• SMILES: [H][C@]1(OC(=O)c2c3OCOc3ccc12)[C@@]1([H])N(C)CCc2cc3OCOc3cc12
• Target: GABA Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.44 mM);DMSO:16.67 mg/mL (45.38 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Bicuculline, (+)-Bicuculline, AHP, alkaloid, d-Bicuculline, convulsant, competitive, inhibit, neurotransmitter, Inhibitor, GABAR, GABA Receptor, GABAReceptor, Gamma-aminobutyric acid Receptor, potassium, γ-Aminobutyric acid Receptor

Quick Database Links

Gene Symbol

GABA Receptor