Binimetinib

SKU: orb1305378

Description

Binimetinib (ARRY-162) is an orally bioavailable, selective MEK1/2 inhibitor (IC50=12 nM). It exhibits antitumor activity and is used in research for unresectable or BRAF V600E/K mutant metastatic melanoma. Its application extends to in vitro signaling studies and in vivo xenograft models investigating MAPK pathway inhibition.

Research Area

Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 606143-89-9
• MW: 441.23
• Purity: >98%
• Formula: C₁₇H₁₅BrF₂N₄O₃
• SMILES: Cn1cnc2c(F)c(Nc3ccc(Br)cc3F)c(cc12)C(=O)NOCCO
• Target: Kinase
• Solubility: Soluble in DMSO (up to at least 25 mg/ml)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ARRY-162; MEK162

Quick Database Links

Gene Symbol

Kinase