BMS-911543

SKU: orb1300463

Description

BMS-911543 is a highly selective JAK2 inhibitor (IC50 = 1.1 nM) with significant selectivity over JAK1, JAK3, and TYK2. It is a valuable research tool for investigating JAK2-dependent pathways in myeloproliferative neoplasms and hematological malignancies, as evidenced in both in vitro and in vivo preclinical studies.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1271022-90-2
• MW: 432.52
• Purity: 97.69% (May vary between batches)
• Formula: C₂₃H₂₈N₈O
• SMILES: CCn1c(cc2c1nc(Nc1cc(C)n(C)n1)c1ncn(C)c21)C(=O)N(C1CC1)C1CC1
• Target: Tyrosine Kinases,Histone Methyltransferase,JAK
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.62 mM);DMSO:34 mg/mL (78.61 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:21 mg/mL (48.55 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SET-2, Tyrosine Kinases, TyrosineKinases, TYK2, BMS 911543, BMS911543, BMS-911543, Inhibitor, HistoneMethyltransferase, Histone Methyltransferase, JAK3, Janus kinase, JAK2, JAK, JAK1, inhibit

Quick Database Links

Gene Symbol

Tyrosine Kinases,Histone Methyltransferase,JAK