Bortezomib

SKU: orb1305542

Description

Bortezomib is a potent, selective, and reversible inhibitor of the 20S proteasome (Ki=0.6 nM). Its antitumor activity is linked to NF-κB inhibition, leading to cell cycle arrest and apoptosis, making it a key tool for cancer research in both cellular and animal models.

Research Area

Cardiovascular Research, Protein Biochemistry

Key Properties

• CAS Number: 179324-69-7
• MW: 384.2
• Purity: >98%
• Formula: C₁₉H₂₅BN₄O₄
• SMILES: CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O
• Target: Proteasome
• Solubility: Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 35 mg/ml).

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MG-341; PS-341; MLN341

Quick Database Links

Gene Symbol

Proteasome