Bosutinib

SKU: orb1310890

Description

Bosutinib (SKI-606) is a dual Abl and Src kinase inhibitor with IC50 values of 1 nM and 1.2 nM, respectively. This synthetic quinolone derivative is widely used in preclinical research for investigating chronic myeloid leukemia (CML) and solid tumors, demonstrating activity in both cellular assays and animal models.

Research Area

Cell Biology, Neuroscience, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 380843-75-4
• MW: 530.6
• Purity: >98%
• Formula: C₂₆H₂₉Cl₂N₅O₃
• SMILES: N(C=1C2=C(C=C(OCCCN3CCN(C)CC3)C(OC)=C2)N=CC1C#N)C4=CC(OC)=C(Cl)C=C4Cl
• Target: Kinase
• Solubility: Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 25 mg/ml with warming).

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SKI-606

Quick Database Links

Gene Symbol

Kinase