C29

SKU: orb1223137

Description

TLR2-IN-C29 is an inhibitor of TLR2/1 and TLR2/6 signaling. It is induced by synthetic and bacterial TLR2 agonists in human HEK-TLR2 and THP-1 cells, but only TLR2/1 signaling in murine macrophages.(In Vitro):C29 (10 or 50 μΜ; 1 hour) blocks P3C- and P2C-induced IL-8 mRNA dose-dependently in HEK-TLR2 stable transfectants. C29 (50-200 μM; 1 hour) inhibits P3C- and P2C-induced IL-1β gene expression significantly at both 1 h and 4 h following stimulation in THP-1 cells.C29 (25 or 50 μΜ; 1 hour) reduces P3C-induced but not P2C-induced TNF-α mRNA and IL-12 p40 protein significantly in primary murine macrophages.C29 (50 μΜ; 1 hour) blocks TLR2 bacterial agonist-induced proinflammatory gene expression in HEK-TLR2 cells and murine macrophages.

Key Properties

• CAS Number: 363600-92-4
• MW: 285.3
• Purity: >98% (HPLC)
• Formula: C₁₆H₁₅NO₄
• SMILES: COc1cccc(\C=N\c2cccc(C(O)=O)c2C)c1O
• Target: Dehydrogenase
• Solubility: DMSO : ≥ 30 mg/mL; 105.16 mM

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TLR2-IN-C29 | TLR2 IN C29 | TLR2INC29 | TLR2-inhibitor-C29

Quick Database Links

Gene Symbol

Dehydrogenase