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CCF642

SKU: orb1223142

Description

CCF-642 is a protein disulfide isomerase (PDI) inhibitor. CCF642 exhibited a submicromolar IC50 in 10 of 10 multiple myeloma cell lines. In vitro, CCF642 inhibited PDI reductase activity about 100-fold more potently than the structurally distinct established inhibitors PACMA 31 and LOC14. CCF642 displayed potent efficacy in an aggressive syngeneic mouse model of multiple myeloma and prolonged the lifespan of C57BL/KaLwRij mice engrafted with 5TGM1-luc myeloma, an effect comparable to the first-line multiple myeloma therapeutic bortezomib.

Images & Validation

Key Properties

CAS Number346640-08-2
MW378.45
Purity>98% (HPLC)
FormulaC15H10N2O4S3
SMILESS1C(=S)N(C(=O)/C/1=C\c1ccc(s1)[N+](=O)[O-])c1ccc(cc1)OC
TargetEGFR
SolubilityDMSO : ≥ 30 mg/mL; 79.27 mM

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

CCF-642 | CCF 642 | CCF642

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  • CCF642 [orb1300453]

    97.12% (May vary between batches)

    346640-08-2

    378.45

    C15H10N2O4S3

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CCF642 (orb1223142)

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Available Sizes

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2 mg
$ 90.00
5 mg
$ 140.00
10 mg
$ 180.00
25 mg
$ 340.00
50 mg
$ 580.00
100 mg
$ 830.00
500 mg
$ 1,820.00