CDC25 Phosphatase Inhibitor I

SKU: orb1221567

Description

BN-82002, also known as CDC25 Phosphatase Inhibitor I, is a cell-permeable ortho-hydroxybenzylamino compound that displays anti-tumor properties. BN-82002 acts as a potent, selective, and irreversible inhibitor of CDC25 phosphatase family (IC50 = 2.4, 3.9, 6.3, 5.4, and 4.6 μM for 25A, 25B2, 25B3, 25C, and 25C-cat, respectively). BN82002 inhibits the phosphatase activity of recombinant human CDC25A, B, and C in vitro. It impairs the proliferation of tumoral cell lines and increases cyclin-dependent kinase 1 inhibitory tyrosine phosphorylation. In synchronized HeLa cells, BN82002 delays cell cycle progression at G1-S, in S phase and at the G2-M transition.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 396073-89-5
• MW: 359.42
• Purity: >98% (HPLC)
• Formula: C₁₉H₂₅N₃O₄
• SMILES: Oc1c(cc(cc1OC)N(C)C)CN(C)CCc2ccc(cc2)[N+]([O-])=O
• Target: Phosphatase
• Solubility: DMSO : ≥ 150 mg/mL; 417.34 mM

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BN-82002 | CDC25 Phosphatase Inhibitor I | PTP Inhibitor XX |

Quick Database Links

Gene Symbol

Phosphatase