Cedirogant

SKU: orb1297964

Description

Cedirogant (ABBV-157) is an orally bioavailable, small molecule inverse agonist of the retinoid-related orphan receptor γt (RORγt). It is utilized in preclinical and clinical research for autoimmune conditions like psoriasis, investigating its mechanism and efficacy in modulating IL-17-driven inflammatory pathways.

Research Area

Metabolism Research

Key Properties

• CAS Number: 2055496-11-0
• MW: 547.78
• Purity: 99.20% (May vary between batches)
• Formula: C₂₄H₂₀Cl₃F₃N₂O₃
• SMILES: OC(=O)CC1CCN(CC1)C(=O)c1ccc(Cl)c(Cn2ccc3cc(cc(Cl)c23)C(F)(F)F)c1Cl
• Target: ROR
• Solubility: DMSO:200 mg/mL (365.11 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (9.13 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, inverse, Cedirogant, agonist, ABBV157, ABBV-157, ABBV 157, RAR-related orphan receptor, RORγt, ROR, psoriasis

Quick Database Links

Gene Symbol

ROR