CHIR-99021

SKU: orb1305728

Description

CHIR-99021 is a potent, selective, and orally active GSK-3α/β inhibitor that activates Wnt/β-catenin signaling. It is widely used in stem cell research to promote self-renewal of embryonic stem cells by inducing autophagy, and has applications in studies of development, metabolism, and regeneration in vitro and in vivo.

Research Area

Cell Biology, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 252917-06-9
• MW: 465.34
• Purity: ≥95% (May vary between batches)
• Formula: C₂₂H₁₈Cl₂N₈
• SMILES: Cc1c[nH]c(n1)-c1cnc(NCCNc2ccc(cn2)C#N)nc1-c1ccc(Cl)cc1Cl
• Target: Wnt/beta-catenin,GSK-3,Autophagy
• Solubility: DMSO: 105 mg/mL (225.64 mM), Sonication is recommended.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Beta catenin, beta-catenin, betacatenin, CHIR 99021, CHIR99021, CHIR-99021, CT99021, CT-99021, CT 99021, Autophagy, bcatenin, Laduviglusib, Inhibitor, Glycogen synthase kinase 3, Glycogen synthase kinase-3, GSK-3β, GSK-3α, GSK3, GSK-3, inhibit, βcatenin, β-catenin, Wnt, Wnt/β-catenin, Wnt/b-catenin, Wnt/betacatenin

Quick Database Links

Gene Symbol

Wnt/beta-catenin,GSK-3,Autophagy