Clozapine N-oxide

SKU: orb1302814

Description

Clozapine N-oxide (CNO) is a brain-penetrant metabolite of clozapine and a potent agonist for DREADD receptors hM3Dq and hM4Di, widely used for chemogenetic neuronal manipulation in vivo. It also exhibits dopaminergic antagonist and muscarinic M4 receptor agonist activities, supporting its use in neuropharmacology research.

Research Area

Neuroscience, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 34233-69-7
• MW: 342.8
• Purity: >98%
• Formula: C₁₈H₁₉ClN₄O
• SMILES: CN1(=O)CCN(C=2C=3C(NC=4C(N2)=CC(Cl)=CC4)=CC=CC3)CC1
• Target: GPCR
• Solubility: Soluble in DMSO (up to 15 mg/ml) or in Ethanol (up to 3 mg/ml)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

hM3Dq, Inhibitor, G-protein, metabolite, mAChR, inhibit, Muscarinic acetylcholine receptor, muscarinic-M4, 5HTReceptor, 5HT Receptor, 5-HT, BBB, Clozapine, CLOZAPINE N OXIDE, CLOZAPINE NOXIDE, Clozapine N-oxide, CLOZAPINE N-OXIDE, DrugMetabolite, Drug Metabolite, DREADDs, Dopamine Receptor, Dopamine, DopamineReceptor

Quick Database Links

Gene Symbol

GPCR