Cobicistat

SKU: orb1300941

Description

Cobicistat (GS-9350) is a pharmacoenhancer used in HIV research that potently inhibits cytochrome P450 3A (CYP3A) enzymes. This inhibition boosts systemic exposure of co-administered antiretroviral drugs like protease inhibitors, a mechanism validated in both in vitro metabolic studies and in vivo pharmacokinetic research for combination therapy.

Research Area

Infectious Disease & Virology, Metabolism Research, Pharmacology & Drug Discovery, Protein Biochemistry

Key Properties

• CAS Number: 1004316-88-4
• MW: 776.02
• Purity: 97.36% (May vary between batches)
• Formula: C₄₀H₅₃N₇O₅S₂
• SMILES: CC(C)c1nc(CN(C)C(=O)N[C@@H](CCN2CCOCC2)C(=O)N[C@H](CC[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)Cc2ccccc2)cs1
• Target: HIV Protease,Cytochromes P450
• Solubility: Ethanol:93 mg/mL (119.84 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (4.25 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:93 mg/mL (119.84 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CYP3A, CYPs, Cytochrome P450, Cobicistat, antiviral, GS 9350, GS9350, GS-9350, Human immunodeficiency virus, HIV, HIV Protease, HIV-1, HIVProtease, inhibit, Inhibitor, Tybost

Quick Database Links

Gene Symbol

HIV Protease,Cytochromes P450