1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea

SKU: orb1305935

Description

SC-1 is a sorafenib-derived small molecule that potently inhibits STAT3 phosphorylation and activation, leading to apoptosis in hepatocellular carcinoma cells. It is used in cancer research, particularly for studying STAT3 signaling pathways in vitro.

Research Area

Cell Biology, Kidney & Urological Research, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1313019-65-6
• MW: 431.8
• Purity: 97.56% (May vary between batches)
• Formula: C₂₁H₁₃ClF₃N₃O₂
• SMILES: FC(F)(F)C1=CC(NC(=O)NC2=CC=C(OC3=CC=C(C=C3)C#N)C=C2)=CC=C1Cl
• Target: STAT,Apoptosis
• Solubility: DMSO:55 mg/mL (127.37 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cyclin-D1, Apoptosis, anticancer, 1 (4 Chloro 3 (trifluoromethyl)phenyl) 3 (4 (4 cyanophenoxy)phenyl)urea, 1(4Chloro3(trifluoromethyl)phenyl)3(4(4cyanophenoxy)phenyl)urea, kinase, Inhibitor, inhibit, orally, SHP-1, p-STAT3, survivin, STAT, STAT3

Quick Database Links

Gene Symbol

STAT,Apoptosis