Cucurbitacin I

SKU: orb1296138

Description

Cucurbitacin I (JSI-124) is a natural product that selectively inhibits the JAK2/STAT3 signaling pathway. It has demonstrated anti-cancer activity in both in vitro cell-based assays and in vivo animal models, making it a valuable research tool for oncology and signal transduction studies.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2222-07-3
• MW: 514.65
• Purity: 96.69% (May vary between batches)
• Formula: C₃₀H₄₂O₇
• SMILES: [H][C@@]12CC=C3[C@@]([H])(C=C(O)C(=O)C3(C)C)[C@]1(C)C(=O)C[C@]1(C)[C@H]([C@H](O)C[C@@]21C)[C@@](C)(O)C(=O)\C=C\C(C)(C)O
• Target: JAK,STAT
• Solubility: DMSO:95 mg/mL (184.59 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2.5 mg/mL (4.86 mM)

Storage & Handling

• Storage: store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cucurbitacin I, Elatericin B, inhibit, JSI 124, JSI124, JSI-124, Inhibitor, NSC 521777, Janus kinase, JAK, JAK2, NSC521777, NSC-521777, STAT, STAT3

Quick Database Links

Gene Symbol

JAK,STAT