Cyclopamine

SKU: orb1304971

Description

Cyclopamine is a steroidal jerveratrum alkaloid that acts as a Smoothened (Smo) antagonist, with an IC50 of 46 nM in TM3Hh12 cells. It is a critical research tool for studying the Hedgehog signaling pathway in both in vitro and in vivo models of development and cancer.

Research Area

Cancer Biology, Cell Biology, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 4449-51-8
• MW: 411.6
• Purity: >98%
• Formula: C₂₇H₄₁NO₂
• SMILES: [H][C@@]12CC3O[C@]4([H])C[C@H](C)CN[C@@]4([H])[C@@H](C)[C@@]3([H])C(C)=C1C[C@@]1([H])[C@@]2([H])CC=C2C[C@@H](O)CC[C@]12C
• Target: GPCR
• Solubility: Soluble in DMSO (up to 4 mg/ml) or in Ethanol (up to 20 mg/ml)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

11-deoxojervine

Quick Database Links

Gene Symbol

GPCR