Darapladib

SKU: orb1301065

Description

Darapladib (SB-480848) is a potent and selective Lp-PLA2 inhibitor with an IC50 of 0.25 nM. It is widely used in cardiovascular disease research to study atherosclerosis mechanisms and has demonstrated protective effects in both in vitro assays and in vivo animal models.

Research Area

Cell Biology, Metabolism Research

Key Properties

• CAS Number: 356057-34-6
• MW: 666.77
• Purity: 98.00% (May vary between batches)
• Formula: C₃₆H₃₈F₄N₄O₂S
• SMILES: C(C(N(CC1=CC=C(C=C1)C2=CC=C(C(F)(F)F)C=C2)CCN(CC)CC)=O)N3C4=C(C(=O)N=C3SCC5=CC=C(F)C=C5)CCC4
• Target: Apoptosis,Phospholipase
• Solubility: DMSO:123.75 mg/mL (185.6 mM);Ethanol:93 mg/mL (139.48 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (6 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Darapladib, Inhibitor, Lp-PLA2, inhibit, Phospholipase, SB 480848, SB480848, SB-480848

Quick Database Links

Gene Symbol

Apoptosis,Phospholipase