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Denifanstat

SKU: orb1308311

Description

Denifanstat (FASN-IN-2, TVB-2640) is a selective, orally active fatty acid synthase (FASN) inhibitor with reported IC50 and EC50 values of 0.052 µM and 0.072 µM, respectively. By inhibiting FASN, denifanstat reduces de novo lipogenesis, a key pathway involved in fatty acid production and metabolic regulation.

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number1399177-37-7
MW439.55
Purity98.33% (May vary between batches)
FormulaC27H29N5O
SMILESCc1n[nH]c(n1)-c1cc(C(=O)N2CCC(CC2)c2ccc(cc2)C#N)c(C)cc1C1CCC1
TargetFatty Acid Synthase
SolubilityDMSO: 262.5 mg/mL (597.2 mM), sonication is recommended.

Customer Validated Data

The data below is submitted by researchers worldwide. We provide this transparency to help you decide if this product works for your specific application or species, even if we haven't tested it ourselves.
Success by Application
In vitro3 experiments
In vivo2 experiments
Reactivity Distribution
Human3 experiments
Mouse2 experiments

Latest Experiments

5 Results
Dilution
Sample
Summary
In vitro
Human
1 μM
HCT116 cells and 786-O cells
Denifanstat was used as a FASN...
In vitro
Human
1 μM
HeLa/DDP cells
Denifanstat was used as a FASN...
In vivo
Mouse
12 mg/kg
Xenograft tumors in mice
Denifanstat was used as a FASN...
In vitro
Human
5 mM
PC-3M cells and C4-2B cells
Denifanstat was used as a FASN...
In vivo
Mouse
100 mg/kg
Xenograft tumors in mice
Denifanstat was used as a FASN...

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

ASC40, ASC-40, ASC 40, COVID-19, Denifanstat, Inhibitor, FASN-IN-2, FASN, Fatty Acid Synthase (FASN), Fatty Acid Synthase, FattyAcidSynthase, inhibit, SARS-CoV2, spike, protein, TVB 2640, TVB2640, TVB-2640
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

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Protocol Information

Denifanstat (orb1308311)

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Available Sizes

Select a size below

1 mg
$ 130.00
5 mg
$ 240.00
1 ml x 10 mM (in DMSO)
$ 270.00
10 mg
$ 380.00
25 mg
$ 600.00
50 mg
$ 830.00
100 mg
$ 1,160.00
500 mg
$ 2,270.00
DispatchUsually dispatched within 3-5 working days
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