Docetaxel trihydrate

SKU: orb1310857

Description

Docetaxel trihydrate is a microtubule-stabilizing antineoplastic agent central to treating solid tumors like breast and lung cancer. It is widely used in both in vitro cytotoxicity assays and in vivo xenograft models to study mechanisms of mitotic inhibition and drug resistance. While generally well-tolerated, it can induce hepatic injury, typically in severe hypersensitivity reactions.

Research Area

Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 148408-66-6
• MW: 861.95
• Purity: 98.68% (May vary between batches)
• Formula: C₄₃H₅₉NO₁₇
• SMILES: O.O.O.CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@]1(C)[C@@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)C(O)C(NC(=O)OC(C)(C)C)c3ccccc3)C(C)=C([C@@H](O)C1=O)C2(C)C
• Target: Microtubule Associated,Apoptosis,Bcl-2 Family
• Solubility: Ethanol:100 mg/mL (116.02 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (4.64 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:100 mg/mL (116.02 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Docetaxel, Docetaxel trihydrate, Docetaxel Trihydrate, Apoptosis, Bcl-2, inhibit, Microtubule/Tubulin, MicrotubuleAssociated, Microtubule Associated, Inhibitor, Tubulin β-1 chain, RP 56976, RP56976, RP-56976, RP56976 (NSC 628503), RP56976 (NSC 628503) Trihydrate, RP-56976 (Trihydrate)

Quick Database Links

Gene Symbol

Microtubule Associated,Apoptosis,Bcl-2 Family