Dolutegravir sodium

SKU: orb1305676

Description

Dolutegravir sodium (DTG) is a potent HIV integrase inhibitor (IC50: 2.7 nM) with activity against several raltegravir-resistant mutants. It is widely used in antiviral research for in vitro mechanistic studies and in vivo models of HIV infection, supporting the development of next-generation antiretroviral therapies.

Research Area

Infectious Disease & Virology, Pharmacology & Drug Discovery, Protein Biochemistry

Key Properties

• CAS Number: 1051375-19-9
• MW: 441.36
• Purity: 98.00% (May vary between batches)
• Formula: C₂₀H₁₈F₂N₃NaO₅
• SMILES: [Na+].C[C@@H]1CCO[C@H]2Cn3cc(C(=O)NCc4ccc(F)cc4F)c(=O)c([O-])c3C(=O)N12
• Target: HIV Protease
• Solubility: DMSO:4.42 mg/mL (10.01 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GSK 1349572, GSK1349572, GSK-1349572, GSK-1349572A, HIV Integrase, HIV Protease, HIV, HIV integrase, HIVProtease, Inhibitor, Human immunodeficiency virus, inhibit, Dolutegravir, Dolutegravir sodium, S/GSK1349572

Quick Database Links

Gene Symbol

HIV Protease