Dorzolamide hydrochloride

SKU: orb1226579

Description

Dorzolamide Hcl(L671152 Hcl; MK507 Hcl) is an anti-glaucoma agent, which is a carbonic anhydrase inhibitor.(In Vitro):Component A, caused by an inward flux of CO2 and its subsequent hydration by CA-II, is blocked by Dorzolamide in a dose-dependent manner with an 50% inhibitory concentration IC50 of 2.4 μM (95% confidence interval: 0.5-10.85 μM).(In Vivo):Dorzolamide (3, 10, or 30 mg/kg/day, ip) synergized mitomycin C exhibits anti-tumor activity in EAC solid tumor models. Dorzolamide produces a dose-dependent decrease in the calculated ratio (relative value of 57.3±1, 25.5±1.8, and 24.3± 0.7 %, respectively).

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 130693-82-2
• MW: 360.9
• Purity: >98% (HPLC)
• Formula: C₁₀H₁₇ClN₂O₄S₃
• SMILES: O=S(C(S1)=CC([C@@H](NCC)C[C@@H]2C)=C1S2(=O)=O)(N)=O.[H]Cl
• Target: Carbonic Anhydrase
• Solubility: Water: 14 mg/mL (38.79 mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

L-671,152 | MK-507

Quick Database Links

Gene Symbol

Carbonic Anhydrase