Doxofylline

SKU: orb1224198

Description

Doxofylline is a phosphodiesterase inhibitor and a xanthine derivative drug for asthma.(In Vitro):Doxofylline (5, 10 μM; 48 h) shows potent protection against LPS-induced epithelial inflammation by reducing PGE2, NO release, and decreasing mitochondrial ROS generation in 16HBE cells.Doxofylline (5, 10 μM; 48 h) suppresses LPS-induced expression of NADPH oxidase subunits and TXNIP 16HBE cells.Doxofylline (5, 10 μM; 48 h) inhibits LPS-induced NLRP3 inflammasome activation and secretion of IL-1b and IL-18, as well as mitigates LPS-mediated SIRT1 reduction.Doxofylline (0.1-10 μM; 15 min) significantly reduces fMLP-induced leukocyte migration in BM cells (fMLP: Formyl-Methionyl-Leucyl-Phenylalanine).(In Vivo):Doxofylline (0.3, 1 mg/kg; i.p.; single) inhibits LPS-induced inflammation in the lungs of mice.Doxofylline (0.3 mg/kg; i.p.; pre-treat; single) notably reduces the adhesion of cells to the vascular tissue and surpresses the expression of LPS-induced ICAM-1 in vivo.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 69975-86-6
• MW: 266.26
• Purity: >98% (HPLC)
• Formula: C₁₁H₁₄N₄O₄
• SMILES: O=C(N1C)N(C)C2=C(N(CC3OCCO3)C=N2)C1=O
• Target: PDE
• Solubility: Ethanol: 2 mg/mL (7.51 mM); Water: 24 mg/mL (90.14 mM); DMSO: 53 mg/mL (199.06 mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Doxofylline | Ansimar | ABC-12-3 | ABC-1213 | ABC 1213 | ALT 07 | DO 309

Quick Database Links

Gene Symbol

PDE