Dyclonine hydrochloride

SKU: orb1224767

Description

Dyclonine is an oral anaesthetic found in Sucrets, an over the counter throat lozenge.(In Vitro):Dyclonine hydrochloride (50 μM; 24 h) sensitizes cancer cells to deficiency of cysteine and GSH.Dyclonine hydrochloride (0-2048 μg/mL; 24 or 48 h) shows significant bactericidal and fungicidal activity.\n(In Vivo):Dyclonine hydrochloride (5 mg/kg; i.p.; single daily for 24 days) sensitizes the involucrin+ differentiated tumor cells to sulfasalazine treatment in vivo.Dyclonine hydrochloride (5 mg/kg; i.p.; single daily for 21 days) suppress the growth of tumors formed by ALDH3A1-expressing gastric cancer stemlike cells when combines with sulfasalazine.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 536-43-6
• MW: 325.87
• Purity: >98% (HPLC)
• Formula: C₁₈H₂₇NO₂·HCl
• SMILES: CCCCOC1=CC=C(C=C1)C(=O)CCN2CCCCC2.Cl
• Target: Sodium Channel
• Solubility: Ethanol: 36 mg/mL (110.47 mM); Water: 6 mg/mL (18.41 mM); DMSO: 15 mg/mL (46.03 mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Dyclonine Hydrochloride | Dyclonine HCL | Dyclone | Dyclothane | Tanaclone | Sucrets | Tanac

Quick Database Links

Gene Symbol

Sodium Channel