Elacridar

SKU: orb1305209

Description

Elacridar (GG918) is a potent, dual inhibitor of the efflux transporters P-glycoprotein and BCRP. It is widely used in pharmacological research to enhance the bioavailability and brain penetration of co-administered drugs in both in vitro and in vivo models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 143664-11-3
• MW: 563.64
• Purity: 98.12% (May vary between batches)
• Formula: C₃₄H₃₃N₃O₅
• SMILES: COc1cc2CCN(CCc3ccc(NC(=O)c4cccc5c4[nH]c4c(OC)cccc4c5=O)cc3)Cc2cc1OC
• Target: P-gp,BCRP
• Solubility: DMSO:7.86 mg/mL (13.95 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cluster of differentiation 243, CD243, Breast cancer resistance protein, 786-O, ABCB1, ABCG2, BCRP, cancer, Inhibitor, inhibit, Multidrug resistance protein 1, MCF-7, MDR1, GW120918, GW-120918, GW 120918, GW 0918, GW0918, GW-0918, Elacridar, GG 918, GF120918, GF-120918, GF 120918, GG-918, GG918, sunitinib, P-glycoprotein, P-gp (P-glycoprotein), P-gp, Pgp

Quick Database Links

Gene Symbol

P-gp,BCRP