EMD638683

SKU: orb1300597

Description

EMD638683 is a potent and selective serum- and glucocorticoid-regulated kinase (SGK) inhibitor with an IC50 of 3 µM. This small molecule is a valuable research tool for investigating SGK1's role in hypertension, renal function, and cellular ion transport in both in vitro and in vivo models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 1181770-72-8
• MW: 364.34
• Purity: 95.47% (May vary between batches)
• Formula: C₁₈H₁₈F₂N₂O₄
• SMILES: CCc1c(C)c(O)ccc1C(=O)NNC(=O)C(O)c1cc(F)cc(F)c1
• Target: SGK
• Solubility: DMSO:50 mg/mL (137.23 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.49 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, EMD638683, EMD-638683, EMD 638683, inhibit, SGK1, SGK, Serum and glucocorticoid-regulated kinase, Serum-glucocorticoid regulated kinase

Quick Database Links

Gene Symbol

SGK

Sheyda Bahiraii er al. Role of Inositol Hexakisphosphate Kinases in Vascular Smooth Muscle Cell Calcification International Journal of Molecular Sciences, (2026)