Epetraborole hydrochloride

SKU: orb1226707

Description

Epetraborole (GSK2251052, AN3365) is a broad-spectrum antibacterial inhibitor of leucyl tRNA-synthetase (LeuRS), shows MIC50/MIC90 of 2/4 ug/ml against 916 clinical anaerobic isolates; MIC90s against 302 Bacteroides fragilis and Bacteroides thetaiotaomicron strains are 4 and 8 μg/ml, respectively; a single amino acid polymorphism (P329) within the editing domain of LeuRS reduces susceptibility to GSK2251052.Bacterial Infection Phase 2 Discontinued

Key Properties

• CAS Number: 1234563-16-6
• MW: 273.521
• Purity: >98% (HPLC)
• Formula: C₁₁H₁₇BClNO₄
• SMILES: B1(C2=C(C=CC=C2OCCCO)C(O1)CN)O.Cl
• Target: Antibacterial
• Solubility: H2O: ≥ 28 mg/mL

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GSK2251052 hydrochloride | AN3365

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Gene Symbol

Antibacterial