Etoposide (VP-16)

SKU: orb1310906

Description

Etoposide (VP-16-213) is a chemotherapeutic topoisomerase II inhibitor that stabilizes the enzyme-DNA complex, blocking DNA replication (IC50=60.3 µM). It is widely used in cancer research to study mechanisms of apoptosis and autophagy in both cellular and animal models of various malignancies.

Research Area

Cell Biology

Key Properties

• CAS Number: 33419-42-0
• MW: 588.6
• Purity: >98%
• Formula: C₂₉H₃₂O₁₃
• SMILES: O=C1[C@@]2([C@@H](C=3C([C@@H](O[C@@H]4O[C@]5([C@]([C@H](O)[C@H]4O)(O[C@H](C)OC5)[H])[H])[C@]2(CO1)[H])=CC6=C(C3)OCO6)C7=CC(OC)=C(O)C(OC)=C7)[H]
• Target: Topoisomerase
• Solubility: Soluble in DMSO (up to 25 mg/ml).

Storage & Handling

• Storage: RT
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NSC 141540

Quick Database Links

Gene Symbol

Topoisomerase