Etravirine

SKU: orb1305326

Description

Etravirine (R165335) is a second-generation diarylpyrimidine NNRTI effective against HIV strains resistant to first-generation NNRTIs. It inhibits reverse transcriptase by binding in multiple conformations. This compound is utilized in antiviral research for both in vitro enzymatic assays and in vivo studies of HIV infection and drug resistance.

Research Area

Infectious Disease & Virology, Pharmacology & Drug Discovery, Protein Biochemistry

Key Properties

• CAS Number: 269055-15-4
• MW: 435.28
• Purity: >98%
• Formula: C₂₀H₁₅BrN₆O
• SMILES: O(C1=NC(NC2=CC=C(C#N)C=C2)=NC(N)=C1Br)C3=C(C)C=C(C#N)C=C3C
• Target: Reverse Transcriptase,HIV Protease
• Solubility: DMSO:250 mg/mL (574.34 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.59 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, Human immunodeficiency virus, HIVProtease, HIV, HIV Protease, Etravirine, inhibit, ReverseTranscriptase, Reverse Transcriptase, TMC 125, TMC125, TMC-125, R165335, R-165335, R 165335

Quick Database Links

Gene Symbol

Reverse Transcriptase,HIV Protease