FG 7142

SKU: orb1309678

Description

FG 7142 is a benzodiazepine inverse agonist with high affinity for α1 subunit-containing GABAA receptors (Ki=91 nM). It modulates GABA-induced chloride flux and has been used in research to study anxiety-related neurochemistry, including in vivo effects on cortical tyrosine hydroxylation and β-adrenoceptor upregulation in mice.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 78538-74-6
• MW: 225.25
• Purity: 98.75% (May vary between batches)
• Formula: C₁₃H₁₁N₃O
• SMILES: CNC(=O)c1cc2c(cn1)[nH]c1ccccc21
• Target: GABA Receptor
• Solubility: DMSO:30 mg/mL (133.19 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.88 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

dopaminergic, FG 7142, FG7142, FG-7142, GABAReceptor, GABA Receptor, GABAA, GABAA receptor, Gamma-aminobutyric acid Receptor, Inhibitor, inhibit, inverse agonist, nucleus accumben, LSU 65, LSU65, LSU-65, ZK39106, ZK-39106, ZK 39106, tyrosine hydroxylase, γ-Aminobutyric acid Receptor

Quick Database Links

Gene Symbol

GABA Receptor